个人简历：

2012-07至今，中日友好医院，临床医学研究所，副研究员（2014-）

2009-12至2012-04，香港大学，医学院生物化学系，博士后

2004-09至2009-12，香港大学，医学院生物化学系，博士，导师：黄建东

2003-07至2004-08，北京大学，生命科学学院，研究助理

1999-09至2003-07，北京大学，生命科学学院，本科，导师：邓宏魁

研究方向：

1. 胰腺神经内分泌肿瘤发病机制及治疗；

2. 肺纤维化的发生机制及治疗；

3. 细胞内运输与病毒入侵。

研究成果：

[1] S. Wu#, J. Zhou#, J. Guo, Z. Hua*, J. Li*, Z. Wang*, Apatinib inhibits tumor growth and angiogenesis in PNET models, Endocr Connect, 8 (2019) 8-19.

[2] Q. Fang, M. Zhai, S. Wu, X. Hu, Z. Hua, H. Sun, J. Guo, W. Zhang, Z. Wang*, Adipocyte-derived stem cell-based gene therapy upon adipogenic differentiation on microcarriers attenuates type 1 diabetes in mice, Stem Cell Res Ther, 10 (2019) 36.

[3] Z. Wang#, L. Liu#, J. Luo, J. Guo, M. Zhai, W. Zhang, Z. Yang*, Uncovering the heterogeneous genetic variations in two insulin-expressing tumors in a patient with MEN1, Oncol Lett, 15 (2018) 7123-7131.

[4] Z. Wang*, L. Peng, Y.L. Song, S. Xu, Z. Hua, N. Fang, M. Zhai, H. Liu, Q. Fang, T. Deng, W. Zhang, Y.J. Chen, J. Lou, Pseudo-hemorrhagic region formation in pancreatic neuroendocrine tumors is a result of blood vessel dilation followed by endothelial cell detachment, Oncol Lett, 15 (2018) 4255-4261.

[5] W. Sun, G. Chen, F. Wang, Y. Qin, Z. Wang*, J. Nie, G. Ma*, Polyelectrolyte-complex multilayer membrane with gradient porous structure based on natural polymers for wound care, Carbohydrate polymers, 181 (2018) 183-190.

[6] Z.Y. Wang#, Z. Wang#, Z.D. Zhen, K.H. Feng, J. Guo, N. Gao, D.Y. Fan, D.S. Han, P.G. Wang*, J. An*, Axl is not an indispensable factor for Zika virus infection in mice, The Journal of general virology, 98 (2017) 2061-2068.

[7] J. You#, Z. Wang#, S. Xu, W. Zhang, Q. Fang, H. Liu, L. Peng, T. Deng, J. Lou, Advanced Glycation End Products Impair Glucose-Stimulated Insulin Secretion of a Pancreatic beta-Cell Line INS-1-3 by Disturbance of Microtubule Cytoskeleton via p38/MAPK Activation, J Diabetes Res, 2016 (2016) 9073037.

[8] Z. Wang#, J. You#, S. Xu, Z. Hua, W. Zhang, T. Deng, N. Fang, Q. Fang, H. Liu, L. Peng, P. Wang, J. Lou*, Colocalization of insulin and glucagon in insulinoma cells and developing pancreatic endocrine cells, Biochem Biophys Res Commun, 461 (2015) 598-604.

[9] Z. Wang, J. Cui, W.M. Wong, X. Li, W. Xue, R. Lin, J. Wang, P. Wang, J.A. Tanner, K.S. Cheah, W. Wu*, J.D. Huang*, Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions, Development, 140 (2013) 617-626.

技术服务特色：

协助临研所超速离心机、双色红外激光成像系统、激光共聚焦显微镜（正置）的使用和维护，熟悉外泌体、慢病毒、质粒超速离心纯化；假病毒包装；双色荧光Western blot；小动物活体成像等操作。