个人简介

2003年北京大学生物技术系获学士学位,2009年香港大学医学院生物化学系获博士学位。现任科技中心基础研究部副主任、仪器平台负责人。研究员,协和、北医、首医、临研所硕导。继往研究包括黄病毒(CSFV、ZIKV)及冠状病毒(SARS-CoV、MERS-CoV、SARS-CoV-2)入侵机制、肺纤维化病理机制及新疗法等。现与呼吸中心开展合作,探索呼吸道病毒感染导致肺及肺外脏器损伤病理机制。以第一或通讯作者在Lancet Infectious Diseases、Cell Discovery、ACS Nano、iScience、Development等杂志发表SCI论文23篇,先后主持国自然青年项目、医科院重大协同创新项目子课题、国自然面上项目、国家重点研发计划子课题等课题7项。

研究方向

病毒性呼吸道新发突发传染病对人类健康造成巨大威胁,新冠病毒和流感病毒已成为两种最受关注的病原体。阐明病毒在宿主体内的感染及播散途径、宿主抗病毒免疫反应、感染损伤及免疫损伤机制,对理解呼吸道病毒引发的呼吸系感染乃至肺外脏器损伤具有重要意义。本课题组利用病毒感染小鼠模型,试图探究以下科学问题:

1.多器官损伤机制:严重的呼吸道病毒感染可能导致肺及肺外器官损伤,不同细胞类群损伤机制是否有所差异?炎症因子风暴还是病毒直接感染是导致肺外器官损伤的原因?是否存在宿主因素影响肺外器官损伤的发生?是有待阐明的问题。

2.血管内皮细胞损伤机制:病毒感染引起血管内皮细胞干扰素、炎症、补体、凝血、泛死亡通路激活,导致细胞功能障碍甚至死亡,对于感染急性期多器官血管内皮屏障功能破坏、凝血系统失稳态具有重要意义。血管内皮细胞功能失调还可能延续到急性期后,对机体产生长期影响。深入理解血管内皮细胞在感染中的作用及机制可能为治疗靶点的发现提供重要线索。

近五年发表文章

1. W Zuo#, D He#, C Liang#, S Du, Z Hua, Q Nie, X Zhou, M Yang, H Tan, J Xu, Y Yu, Y Zhan, Y Zhang, X Gu, W Zhu, H Zhang, H Li, W Sun, M Sun, X Liu, L Liu, C Cao, R Li, J Li, Y Zhang, Y Zhang, J Guo, L Zhao, CP Zhang, H Liu, S Wang, F Xiao, Y Wang, Z Wang*, H Li*, B Cao*, The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China, Lancet Infectious Diseases, 2024 Apr 22; S1473-3099(24)00171-3. (IF 36.4)

2. Peipei Liu#，Shengnan Yang#，Xuecheng Shao, Zai Wang*，Huaping Dai*，Chen Wang*, Mesenchymal stem cells-derived exosomes alleviate acute lung injury by inhibiting alveolar macrophage pyroptosis, Stem Cells Translational Medicine, 2024 Apr 15; 13(4):371-386. doi: 10.1093/stcltm/szad094. (IF 5.4)

3. Zhan Hua#, Shan Wu#, Yulian Zhang#, Xiuhong Wang, Ju Cui, Yunxuan Li, Chengcheng Yang, Min Zhai, Bo Deng, Bin Yu, Jian-Dong Huang, Zai Wang* and Jianjun Zhou*, Targeted IFNγ induction by a genetically engineered Salmonella typhimurium is the key to the liver metastasis inhibition in a mouse model of pancreatic neuroendocrine tumor, Frontiers in Medicine, 10:1284120 (IF 3.1)

4. Pengfei Pei#, Long Chen*, Ruru Fan, Xi-Rui Zhou, Shan Feng, Hangrui Liu, Quanqiang Guo, Huiwei Yin, Qiang Zhang, Fude Sun, Liang Peng, Peng Wei, Chengzhi He, Renzhong Qiao, Zai Wang*, and Shi-Zhong Luo*, Computer-Aided Design of Lasso-like Self Assembling Anticancer Peptides with Multiple Functions for Targeted Self-Delivery and Cancer Treatments, ACS Nano, 2022, 16:13783–13799 (IF 18.0)

5. Shengnan Yang #, Peipei Liu #, Tingting Gao #, Dingyun Song, Xinyu Zhao, Yupeng Li, Jun Wu, Liu Wang, Zai Wang*, Jie Hao*, Chen Wang*, Huaping Dai*, Every road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes, Stem Cell Research &Therapy, 2022, 13:163. (IF 6.8)

6. Z. Wang#, T. Deng#, Y. Zhang#, W. Niu, Q. Nie, S. Yang, P. Liu, P. Pei, L. Chen, H. Li*, B. Cao*, ACE2 can act as the secondary receptor in the FcgammaR-dependent ADE of SARS-CoV-2 infection, iScience, 2022, 25:103720. (IF 5.4)

7. Peipei Liu#, Shengnan Yang#, Zai Wang*, Huaping Dai*, Chen Wang*, Feasibility and Mechanism Analysis of Shenfu Injection in the Treatment of Idiopathic Pulmonary Fibrosis, Front Pharmacol, 2021, 12:670146. (IF 5.8)

8. PG. Wang, DJ. Tang, Z. Hua, Z. Wang*, J. An*, Sunitinib reduces the infection of SARS-CoV, MERS-CoV and SARS-CoV-2 partially by inhibiting AP2M1 phosphorylation, Cell Discov, 2020, 6:71. (IF 10.8)

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